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Hypoxia-inducible factor-1 HIF-1 mediates the transcriptional response to hypoxic stress, promoting tumour progression and survival. Treatment response was measured using magnetic Rochdale city centre escort spectroscopy and imaging. Ex-vivo histological validation of imaging findings was also sought. Increased glutamine metabolism was independent of c-Myc, a factor also downregulated by NSC NSC induces metabolic alterations in vitro and early anti-tumour activity in vivoindependent of changes in vascular function.

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Our data support the further evaluation of NSC as an anti-cancer agent. Solid tumours typically exhibit hypoxic regions that are associated with a corrning aggressive phenotype, impacting negatively on treatment response and patient survival Gray et al, ; Vaupel et al, ; Gays Livingston in et al, A key mediator of hypoxic cell survival and adaptation is the hypoxia-inducible factor-1 HIF-1 pathway Semenza, Translocation of HIF-1 to the nucleus and binding to hypoxic response elements leads to the transcription and translation of numerous genes Semenza et al, ; Carmeliet et al, ; Pugh and Cirning, Importantly, many of the upregulated genes have recognised functions in tumourigenesis, modulating tumour metabolism, and enhancing angiogenesis, invasion and Singles corning Royal Leamington Spa Maxwell et al, ; Semenza, ; Robey et al, Given the diversity of the pathogenic pathways involved, compounds that target HIF-1 or components of the HIF pathway are actively being sought, and several small-molecule inhibitors of the HIF pathway are currently in clinical trials Onnis et al, ; Tennant et al, ❶Please enter your password Forgotten your password?

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NSC induces metabolic alterations in vitro and early anti-tumour activity in vivoindependent of changes in vascular function. Fitness Adventures Midlands. Photo by Phil Hutchinson.

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